AKT

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells. (mesh:D051057)

Cross-references

• RE:R-HSA-202088
• RE:R-HSA-2400013
• RE:R-HSA-2400006
• SIGNOR:SIGNOR-PF24
• MESH:D051057 - Proto-Oncogene Proteins c-akt
• RE:R-HSA-202074
• MEDSCAN:urn:agi-aopfc:0000439
• NCIT:C41625
• BEL:AKT Family
• RE:R-HSA-202072
• RE:R-HSA-202052
• RE:R-HSA-2317310
• RE:R-HSA-2317329
• SFAM:F0014
• RE:R-HSA-2317317

Synonyms

Synonym	Reference	Specificity
PKB-Akt		Exact
PKB/Akt		Exact
AKT family		Exact
Akt		Exact
PKB		Exact
AKT		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:393	AKT3	isa
HGNC:392	AKT2	isa
HGNC:391	AKT1	isa

Outgoing Relations

None available.