Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells. (mesh:D051057)



Synonym Reference Specificity
PKB/Akt Exact
AKT Exact
Akt Exact
AKT family Exact
PKB-Akt Exact
PKB Exact

Incoming Relations

Identifier Name Relation
HGNC:392 AKT2 isa
HGNC:393 AKT3 isa
HGNC:391 AKT1 isa

Outgoing Relations

None available.