ANO

A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding. (mesh:D000075368)

Cross-references

Synonyms

None available.

Incoming Relations

Identifier Name Relation
HGNC:27337 ANO5 isa
HGNC:1183 ANO2 isa
HGNC:23837 ANO4 isa
HGNC:21625 ANO1 isa
HGNC:14004 ANO3 isa
HGNC:20679 ANO9 isa
HGNC:29329 ANO8 isa
HGNC:25240 ANO6 isa
HGNC:31677 ANO7 isa
HGNC:25519 ANO10 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Chloride_calcium_activated_channels Chloride_calcium_activated_channels