ARRB

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling. (mesh:D000071557)

Cross-references

• RE:R-HSA-1911410
• MESH:D000071557 - beta-Arrestins
• SFAM:F0018
• BEL:ARRB Family

Synonyms

Synonym	Reference	Specificity
b-arrestin		Exact
barrestins		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:712	ARRB2	isa
HGNC:711	ARRB1	isa

Outgoing Relations

None available.