Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling. (mesh:D000071557)



Synonym Reference Specificity
b-arrestin Exact
barrestins Exact

Incoming Relations

Identifier Name Relation
HGNC:711 ARRB1 isa
HGNC:712 ARRB2 isa

Outgoing Relations

None available.