A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2. (mesh:D000075002)
| Identifier | Name | Relation |
| HGNC:17105 | BEST3 | isa |
| HGNC:17106 | BEST4 | isa |
| HGNC:17107 | BEST2 | isa |
| HGNC:12703 | BEST1 | isa |
| Relation | Identifier | Name |
| isa | FPLX:Chloride_calcium_activated_channels | Chloride_calcium_activated_channels |