BEST

A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2. (mesh:D000075002)

Cross-references

Synonyms

None available.

Incoming Relations

Identifier Name Relation
HGNC:17107 BEST2 isa
HGNC:17105 BEST3 isa
HGNC:17106 BEST4 isa
HGNC:12703 BEST1 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Chloride_calcium_activated_channels Chloride_calcium_activated_channels