BIRC

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity. (mesh:D051034)

Cross-references

• IP:IPR001370
• MESH:D051034 - Inhibitor of Apoptosis Proteins
• BEL:BIRC Family
• SFAM:F0022

Synonyms

Synonym	Reference	Specificity
BIRs		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:13516	BIRC6	isa
HGNC:593	BIRC5	isa
HGNC:14878	BIRC8	isa
HGNC:592	XIAP	isa
HGNC:7634	NAIP	isa
HGNC:591	BIRC3	isa
HGNC:590	BIRC2	isa
HGNC:13702	BIRC7	isa

Outgoing Relations

None available.