A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity. (mesh:D051034)



Synonym Reference Specificity
BIRs Exact

Incoming Relations

Identifier Name Relation
HGNC:13516 BIRC6 isa
HGNC:593 BIRC5 isa
HGNC:14878 BIRC8 isa
HGNC:13702 BIRC7 isa
HGNC:591 BIRC3 isa
HGNC:590 BIRC2 isa
HGNC:592 XIAP isa
HGNC:7634 NAIP isa

Outgoing Relations

None available.