CAPN

Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4. (mesh:D002154)

Cross-references

• SFAM:F0029
• IP:IPR022684
• RE:R-HSA-8848668
• GO:GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
• MESH:D002154 - Calpain
• NCIT:C16377
• RE:R-HSA-8848649
• BEL:CAPN Family

Synonyms

Synonym	Reference	Specificity
calpain		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:16663	CAPN13	isa
HGNC:1478	CAPN11	isa
HGNC:1476	CAPN1	isa
HGNC:1486	CAPN9	isa
HGNC:11182	CAPN15	isa
HGNC:16664	CAPN14	isa
HGNC:1480	CAPN3	isa
HGNC:1483	CAPN6	isa
HGNC:1482	CAPN5	isa
HGNC:1485	CAPN8	isa
HGNC:1477	CAPN10	isa
HGNC:1484	CAPN7	isa
HGNC:13249	CAPN12	isa
HGNC:1479	CAPN2	isa

Outgoing Relations

None available.