Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC (mesh:D002154)



Synonym Reference Specificity
calpain Exact

Incoming Relations

Identifier Name Relation
HGNC:1478 CAPN11 isa
HGNC:1477 CAPN10 isa
HGNC:1484 CAPN7 isa
HGNC:1486 CAPN9 isa
HGNC:1480 CAPN3 isa
HGNC:16663 CAPN13 isa
HGNC:1476 CAPN1 isa
HGNC:1479 CAPN2 isa
HGNC:1483 CAPN6 isa
HGNC:11182 CAPN15 isa
HGNC:13249 CAPN12 isa
HGNC:1485 CAPN8 isa
HGNC:16664 CAPN14 isa
HGNC:1482 CAPN5 isa

Outgoing Relations

None available.