CATSPER

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca 2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems. (hgnc.genefamily:186)

Cross-references

Synonyms

None available.

Incoming Relations

Identifier Name Relation
HGNC:25243 CATSPERG isa
HGNC:20500 CATSPERB isa
HGNC:17116 CATSPER1 isa
HGNC:23220 CATSPER4 isa
HGNC:18810 CATSPER2 isa
HGNC:28598 CATSPERD isa
HGNC:20819 CATSPER3 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Voltage_gated_ion_channels Voltage_gated_ion_channels
isa FPLX:Calcium_channels Calcium_channels