CD3

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). (mesh:D017252)

Cross-references

• SCOMP:C0022
• BEL:CD3 Complex
• NCIT:C38897
• MESH:D017252 - CD3 Complex
• MEDSCAN:urn:agi-complex:CD3%20complex

Synonyms

Synonym	Reference	Specificity
CD3		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:1675	CD3G	partof
HGNC:1674	CD3E	partof
HGNC:1673	CD3D	partof
HGNC:1677	CD247	partof

Outgoing Relations

None available.