CD3

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). (mesh:D017252)

Cross-references

Synonyms

Synonym Reference Specificity
CD3 Exact

Incoming Relations

Identifier Name Relation
HGNC:1673 CD3D partof
HGNC:1674 CD3E partof
HGNC:1675 CD3G partof
HGNC:1677 CD247 partof

Outgoing Relations

None available.