CLK family members have shown to interact with, and phosphorylate, serine / arginine -rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. (hgnc.genefamily:480)
| Identifier | Name | Relation |
| HGNC:2068 | CLK1 | isa |
| HGNC:2069 | CLK2 | isa |
| HGNC:13659 | CLK4 | isa |
| HGNC:2071 | CLK3 | isa |