CYP
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
(mesh:D003577)
Cross-references
Synonyms
| Synonym |
Reference |
Specificity |
| CYP genes |
|
Exact
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| CYP |
|
Exact
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| p450 |
|
Exact
|
| cytochrome P-450 enzymes |
|
Exact
|
| CYP450 enzymes |
|
Exact
|
| Cytochrome P450 |
|
Exact
|
| CYP isozymes |
|
Exact
|
| CYP450 |
|
Exact
|
| cytochrome |
|
Exact
|
| P450s |
|
Exact
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| Cytochrome P-450 |
|
Exact
|
| CYPs |
|
Exact
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| CYP enzymes |
|
Exact
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| cytochrome P-450 |
|
Exact
|
| Cytochrome p450 |
|
Exact
|
| cytochrome P-450 isozymes |
|
Exact
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| cytochrome p450 |
|
Exact
|
| P450 |
|
Exact
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| CYP enzyme |
|
Exact
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| cytochrome P450s |
|
Exact
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| CYP gene |
|
Exact
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| cytochromes P-450 |
|
Exact
|
| cytochrome P450 |
|
Exact
|
| CYP isoforms |
|
Exact
|
| cytochrome P-450 enzyme |
|
Exact
|
| CYP450 enzyme |
|
Exact
|
Incoming Relations
Outgoing Relations
None available.