CYP

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. (mesh:D003577)

Cross-references

Synonyms

Synonym Reference Specificity
cytochrome P450 Exact
CYP gene Exact
Cytochrome P-450 Exact
CYP450 enzymes Exact
CYP genes Exact
cytochrome P450s Exact
CYP Exact
cytochrome P-450 Exact
cytochrome p450 Exact
CYP450 enzyme Exact
CYP enzyme Exact
cytochrome P-450 enzymes Exact
cytochrome Exact
P450 Exact
cytochromes P-450 Exact
CYP isozymes Exact
CYP450 Exact
cytochrome P-450 isozymes Exact
CYPs Exact
Cytochrome p450 Exact
P450s Exact
CYP enzymes Exact
Cytochrome P450 Exact
p450 Exact
CYP isoforms Exact
cytochrome P-450 enzyme Exact

Incoming Relations

Identifier Name Relation
HGNC:2600 CYP21A2 isa
HGNC:2594 CYP19A1 isa
FPLX:CYP7 CYP7 isa
FPLX:CYP_epoxygenases CYP_epoxygenases isa
FPLX:CYP4 CYP4 isa
FPLX:CYP11 CYP11 isa
HGNC:2602 CYP24A1 isa
HGNC:2641 CYP46A1 isa
FPLX:CYP1 CYP1 isa
FPLX:CYP26 CYP26 isa
HGNC:2593 CYP17A1 isa
FPLX:CYP27 CYP27 isa
FPLX:CYP8 CYP8 isa
FPLX:CYP2 CYP2 isa
HGNC:11609 TBXAS1 isa
FPLX:CYP3 CYP3 isa
HGNC:2649 CYP51A1 isa
HGNC:17449 CYP39A1 isa
HGNC:20576 CYP20A1 isa

Outgoing Relations

None available.