Caspase

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur. (mesh:D020169)

Cross-references

• BEL:CASP Family
• NCIT:C18153
• PF:PF00656
• MESH:D020169 - Caspases
• SFAM:F0031
• IP:IPR002138
• GO:GO:0004199
• IP:IPR033139

Synonyms

Synonym	Reference	Specificity
caspase		Exact
caspases		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:1500	CASP10	isa
HGNC:1499	CASP1	isa
FPLX:Caspase_3_7	Caspase_3_7	isa
HGNC:1507	CASP6	isa
HGNC:1505	CASP4	isa
HGNC:19004	CASP12	isa
HGNC:1511	CASP9	isa
HGNC:1502	CASP14	isa
HGNC:1506	CASP5	isa
HGNC:1509	CASP8	isa
HGNC:1503	CASP2	isa

Outgoing Relations

None available.