Caspase

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur. (mesh:D020169)

Cross-references

Synonyms

Synonym Reference Specificity
caspase Exact
caspases Exact

Incoming Relations

Identifier Name Relation
FPLX:Caspase_3_7 Caspase_3_7 isa
HGNC:1509 CASP8 isa
HGNC:1503 CASP2 isa
HGNC:1505 CASP4 isa
HGNC:1499 CASP1 isa
HGNC:1506 CASP5 isa
HGNC:19004 CASP12 isa
HGNC:1507 CASP6 isa
HGNC:1511 CASP9 isa
HGNC:1500 CASP10 isa
HGNC:1502 CASP14 isa

Outgoing Relations

None available.