DDR

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX. (mesh:D000070818)

Cross-references

• SFAM:F0064
• PF:PF08841
• MESH:D000070818 - Discoidin Domain Receptors
• MEDSCAN:urn:agi-aopfc:0000252
• BEL:DDR Family

Synonyms

Synonym	Reference	Specificity
discoidin domain receptor family		Exact
discoidin domain-containing receptor		Exact
discoidin domain receptors		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:2730	DDR1	isa
HGNC:2731	DDR2	isa

Outgoing Relations

None available.