DDR

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX. (mesh:D000070818)

Cross-references

Synonyms

Synonym Reference Specificity
discoidin domain receptors Exact
discoidin domain-containing receptor Exact
discoidin domain receptor family Exact

Incoming Relations

Identifier Name Relation
HGNC:2730 DDR1 isa
HGNC:2731 DDR2 isa

Outgoing Relations

None available.