DVL

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY. (mesh:D000072261)

Cross-references

• RE:R-HSA-4652685
• RE:R-HSA-1504201
• BEL:DVL Family
• SIGNOR:SIGNOR-PF10
• PF:PF02377
• RE:R-HSA-3858467
• RE:R-HSA-201689
• RE:R-HSA-3772407
• RE:R-HSA-3858479
• PF:PF08137
• SFAM:F0069
• RE:R-HSA-201725
• MESH:D000072261 - Dishevelled Proteins

Synonyms

Synonym	Reference	Specificity
Dvl		Exact
dishevelled		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:3084	DVL1	isa
HGNC:3086	DVL2	isa
HGNC:3087	DVL3	isa

Outgoing Relations

None available.