A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY. (mesh:D000072261)



Synonym Reference Specificity
Dvl Exact
dishevelled Exact

Incoming Relations

Identifier Name Relation
HGNC:3084 DVL1 isa
HGNC:3086 DVL2 isa
HGNC:3087 DVL3 isa

Outgoing Relations

None available.