Death_receptor

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. (mesh:D053218)

Cross-references

• MESH:D053218 - Receptors, Death Domain
• GO:GO:0005035 - death receptor activity

Synonyms

Synonym	Reference	Specificity
death receptor		Exact
death receptors		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:11904	TNFRSF10A	isa
HGNC:11920	FAS	isa
HGNC:11906	TNFRSF10C	isa
HGNC:11905	TNFRSF10B	isa
HGNC:11907	TNFRSF10D	isa
HGNC:11917	TNFRSF1B	isa
HGNC:11916	TNFRSF1A	isa

Outgoing Relations

None available.