A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. (mesh:D053218)



Synonym Reference Specificity
death receptor Exact
death receptors Exact

Incoming Relations

Identifier Name Relation
HGNC:11916 TNFRSF1A isa
HGNC:11906 TNFRSF10C isa
HGNC:11920 FAS isa
HGNC:11907 TNFRSF10D isa
HGNC:11917 TNFRSF1B isa
HGNC:11905 TNFRSF10B isa
HGNC:11904 TNFRSF10A isa

Outgoing Relations

None available.