A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. (mesh:D044767)
| Synonym | Reference | Specificity |
| E3 ubiquitin ligase | Exact | |
| E3 | Exact |