EDN

21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides. (mesh:D016232)

Cross-references

• MESH:D016232 - Endothelins
• HGNC_GROUP:1908
• RE:R-HSA-388544
• MEDSCAN:urn:agi-protfc:endothelin
• IP:IPR001928
• BEL:EDN Family
• IP:IPR019764
• IP:IPR020475
• PF:PF00322
• SFAM:F0071

Synonyms

Synonym	Reference	Specificity
endothelin		Exact
endothelins		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:3177	EDN2	isa
HGNC:3178	EDN3	isa
HGNC:3176	EDN1	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:Neuropeptides	Neuropeptides