21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides. (mesh:D016232)



Synonym Reference Specificity
endothelin Exact
endothelins Exact

Incoming Relations

Identifier Name Relation
HGNC:3177 EDN2 isa
HGNC:3178 EDN3 isa
HGNC:3176 EDN1 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Neuropeptides Neuropeptides