The [fermitin or] kindlin family of proteins each contain a bipartite FERM domain comprising four subdomains F0, F1, F2, and F3 that show homology with the FERM head (H) domain of the cytoskeletal Talin protein. Kindlins have been linked to Kindler syndrome, leukocyte adhesion deficiency, cancer and other acquired human diseases. They are essential in the organisation of focal adhesions that mediate cell-extracellular matrix junctions and are involved in other cellular compartments that control cell-cell contacts and nucleus functioning. Therefore they are responsible for cell to cell crosstalk via cell-cell contacts and integrin mediated cell adhesion through focal adhesion proteins and as specialised adhesion structures of hematopoietic cells they are also present in podosome's F actin surrounding ring structure. (hgnc.genefamily:561)



Synonym Reference Specificity
kindlin Exact
Fermitins Exact
kindlins Exact
Kindlin Exact
fermitins Exact
Kindlins Exact
fermitin Exact
Fermitin Exact

Incoming Relations

Identifier Name Relation
HGNC:23151 FERMT3 isa
HGNC:15767 FERMT2 isa
HGNC:15889 FERMT1 isa

Outgoing Relations

None available.