GAD

A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15. (mesh:D005968)

Cross-references

• MESH:D005968 - Glutamate Decarboxylase

Synonyms

Synonym	Reference	Specificity
glutamic acid decarboxylase		Exact
glutamate decarboxylase		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:4093	GAD2	isa
HGNC:4092	GAD1	isa

Outgoing Relations

None available.