GPCR_C

The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors. Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region. (hgnc.genefamily:275)

Cross-references

• HGNC_GROUP:275

Synonyms

Synonym	Reference	Specificity
Class C GPCR		Exact

Incoming Relations

Identifier	Name	Relation
FPLX:GRM	GRM	isa
FPLX:Calcium_sensing_receptors	Calcium_sensing_receptors	isa
FPLX:GPCR_C_orphans	GPCR_C_orphans	isa
FPLX:GABBR	GABBR	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:GPCR	GPCR