GPCR_C

The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors. Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region. (hgnc.genefamily:275)

Cross-references

Synonyms

Synonym Reference Specificity
Class C GPCR Exact

Incoming Relations

Identifier Name Relation
FPLX:GRM GRM isa
FPLX:Calcium_sensing_receptors Calcium_sensing_receptors isa
FPLX:GABBR GABBR isa
FPLX:GPCR_C_orphans GPCR_C_orphans isa

Outgoing Relations

Relation Identifier Name
isa FPLX:GPCR GPCR