GPIb_IX_V

Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome. (mesh:D019038)

Cross-references

• GO:GO:1990779 - glycoprotein Ib-IX-V complex
• MESH:D019038 - Platelet Glycoprotein GPIb-IX Complex
• RE:R-HSA-114668
• BEL:Ib-V-IX Complex
• SCOMP:C0063
• NCIT:C126122

Synonyms

Synonym	Reference	Specificity
Glycoprotein Ib-V-IX		Exact
GPIb-IX-V complex		Exact
Glycoprotein Ib/V/IX		Exact
GPIb-IX-V		Exact
GpIb-V-IX		Exact
glycoprotein Ib-V-IX complex		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:4444	GP9	partof
HGNC:4443	GP5	partof
HGNC:4440	GP1BB	partof
HGNC:4439	GP1BA	partof

Outgoing Relations

None available.