Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome. (mesh:D019038)



Synonym Reference Specificity
glycoprotein Ib-V-IX complex Exact
GPIb-IX-V complex Exact
Glycoprotein Ib-V-IX Exact
Glycoprotein Ib/V/IX Exact
GPIb-IX-V Exact
GpIb-V-IX Exact

Incoming Relations

Identifier Name Relation
HGNC:4439 GP1BA partof
HGNC:4444 GP9 partof
HGNC:4443 GP5 partof
HGNC:4440 GP1BB partof

Outgoing Relations

None available.