GRIN

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. (mesh:D016194)

Cross-references

• HGNC_GROUP:1201
• SIGNOR:SIGNOR-PF56
• GO:GO:0017146 - NMDA selective glutamate receptor complex
• MESH:D016194 - Receptors, N-Methyl-D-Aspartate

Synonyms

Synonym	Reference	Specificity
NMDA receptor		Exact
NMDA Receptor		Exact
NMDAR		Exact
NMDA receptors		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:16767	GRIN3A	partof
HGNC:4585	GRIN2A	partof
HGNC:16768	GRIN3B	partof
HGNC:4588	GRIN2D	partof
HGNC:4587	GRIN2C	partof
HGNC:4584	GRIN1	partof
HGNC:4586	GRIN2B	partof

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:GRI	GRI