GRIN

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. (mesh:D016194)

Cross-references

Synonyms

Synonym Reference Specificity
NMDA receptor Exact
NMDA Receptor Exact
NMDAR Exact
NMDA receptors Exact

Incoming Relations

Identifier Name Relation
HGNC:16767 GRIN3A partof
HGNC:4585 GRIN2A partof
HGNC:4584 GRIN1 partof
HGNC:16768 GRIN3B partof
HGNC:4587 GRIN2C partof
HGNC:4586 GRIN2B partof
HGNC:4588 GRIN2D partof

Outgoing Relations

Relation Identifier Name
isa FPLX:GRI GRI