HDAC

Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes. (mesh:D006655)

Cross-references

• ECCODE:3.5.1.98 - Histone deacetylase
• NCIT:C16682
• MEDSCAN:urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b
• BEL:HDAC Family
• IP:IPR003084
• SFAM:F0107
• MESH:D006655 - Histone Deacetylases

Synonyms

Synonym	Reference	Specificity
histone deacetylase		Exact
HDAC		Exact
histone deacetylases		Exact

Incoming Relations

Identifier	Name	Relation
FPLX:HDAC_II	HDAC_II	isa
FPLX:HDAC_IV	HDAC_IV	isa
FPLX:HDAC_III	HDAC_III	isa
FPLX:HDAC_I	HDAC_I	isa

Outgoing Relations

None available.