IFNAR

A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE. (mesh:D053633)

Cross-references

• SIGNOR:SIGNOR-C243
• MESH:D053633 - Receptor, Interferon alpha-beta

Synonyms

Synonym	Reference	Specificity
IFNAR		Exact
Interferon-alpha/beta receptor		Exact
Ifnar		Exact
interferon-α/β receptor		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:5432	IFNAR1	isa
HGNC:5433	IFNAR2	isa

Outgoing Relations

None available.