A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (mesh:D020672)
| Identifier | Name | Relation |
| HGNC:1974 | CHUK | isa |
| HGNC:14552 | IKBKE | isa |
| HGNC:5960 | IKBKB | isa |
| HGNC:5961 | IKBKG | isa |
| HGNC:11584 | TBK1 | isa |