IRS

A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. (mesh:D055504)

Cross-references

• PF:PF02174
• BEL:IRS Family
• MEDSCAN:urn:agi-aopfc:0000585
• MESH:D055504 - Insulin Receptor Substrate Proteins
• RE:R-HSA-2445139
• RE:R-HSA-2445131
• SFAM:F0128

Synonyms

Synonym	Reference	Specificity
IRS family		Exact
insulin receptor substrate		Exact
IRS		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:6126	IRS2	isa
HGNC:6128	IRS4	isa
HGNC:6125	IRS1	isa

Outgoing Relations

None available.