A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. (mesh:D055504)



Synonym Reference Specificity
IRS family Exact
IRS Exact
insulin receptor substrate Exact

Incoming Relations

Identifier Name Relation
HGNC:6128 IRS4 isa
HGNC:6126 IRS2 isa
HGNC:6125 IRS1 isa

Outgoing Relations

None available.