Integrins

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. (mesh:D016023)

Cross-references

• NCIT:C16748
• GO:GO:0008305 - integrin complex
• MEDSCAN:urn:agi-complex:MAC-1%20(integrin)
• MESH:D016023 - Integrins
• HGNC_GROUP:597

Synonyms

Synonym	Reference	Specificity
integrin receptors		Exact
integrin		Exact
integrins		Exact

Incoming Relations

Identifier	Name	Relation
FPLX:FNR	FNR	isa
FPLX:MAC_1	MAC_1	isa
FPLX:VTNR	VTNR	isa
FPLX:ITGA	ITGA	isa
FPLX:ITGA2B1	ITGA2B1	isa
FPLX:LFA_1	LFA_1	isa
FPLX:ITGB	ITGB	isa
FPLX:ITGA2B3	ITGA2B3	isa

Outgoing Relations

None available.