Integrins

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. (mesh:D016023)

Cross-references

Synonyms

Synonym Reference Specificity
integrin Exact
integrin receptors Exact
integrins Exact

Incoming Relations

Identifier Name Relation
FPLX:ITGA2B1 ITGA2B1 isa
FPLX:ITGA2B3 ITGA2B3 isa
FPLX:VTNR VTNR isa
FPLX:ITGB ITGB isa
FPLX:FNR FNR isa
FPLX:LFA_1 LFA_1 isa
FPLX:MAC_1 MAC_1 isa
FPLX:ITGA ITGA isa

Outgoing Relations

None available.