A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains. (mesh:D053612)



Synonym Reference Specificity
JAK Exact
Jak Exact
JAKs Exact

Incoming Relations

Identifier Name Relation
HGNC:6193 JAK3 isa
HGNC:12440 TYK2 isa
HGNC:6190 JAK1 isa
HGNC:6192 JAK2 isa

Outgoing Relations

None available.