JNK

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION. (mesh:D048031)

Cross-references

• RE:R-HSA-450253
• RE:R-HSA-450226
• IP:IPR008351
• SFAM:F0135
• RE:R-HSA-450289
• BEL:MAPK JNK Family
• MESH:D048031 - JNK Mitogen-Activated Protein Kinases
• MEDSCAN:urn:agi-aopfc:0000473
• SIGNOR:SIGNOR-PF15

Synonyms

Synonym	Reference	Specificity
JNK MAPK		Exact
c-JNK		Exact
c-Jun N-terminal kinase		Exact
JNK		Exact
SAPK		Exact
JNKs		Exact
JNK1/2		Exact
c-Jun NH2-terminal kinase		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:6886	MAPK9	isa
HGNC:6872	MAPK10	isa
HGNC:6881	MAPK8	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:MAPK	MAPK