LFA_1

An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1. (mesh:D016169)

Cross-references

• SIGNOR:SIGNOR-C169
• MESH:D016169 - Lymphocyte Function-Associated Antigen-1

Synonyms

Synonym	Reference	Specificity
LFA-1		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:6155	ITGB2	partof
HGNC:6148	ITGAL	partof

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:Integrins	Integrins