MAC

A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC. (mesh:D015938)

Cross-references

• RE:R-HSA-8852568
• RE:R-HSA-173728
• SIGNOR:SIGNOR-C313
• SCOMP:C0078
• BEL:Membrane Attack Complex
• MESH:D015938 - Complement Membrane Attack Complex
• GO:GO:0005579 - membrane attack complex

Synonyms

Synonym	Reference	Specificity
membrane attack		Exact
membrane attack complex		Exact
MAC		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:1354	C8G	partof
HGNC:1346	C7	partof
HGNC:1331	C5	partof
HGNC:1352	C8A	partof
HGNC:1339	C6	partof
HGNC:1358	C9	partof
HGNC:1353	C8B	partof

Outgoing Relations

None available.