A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC. (mesh:D015938)



Synonym Reference Specificity
membrane attack Exact
membrane attack complex Exact
MAC Exact

Incoming Relations

Identifier Name Relation
HGNC:1346 C7 partof
HGNC:1339 C6 partof
HGNC:1354 C8G partof
HGNC:1352 C8A partof
HGNC:1353 C8B partof
HGNC:1358 C9 partof
HGNC:1331 C5 partof

Outgoing Relations

None available.