Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). (mesh:D020930)
| Synonym | Reference | Specificity |
| MAPK kinase kinase | Exact | |
| MAPKK kinases | Exact | |
| MAPKKK | Exact | |
| MAP3K | Exact |
| Identifier | Name | Relation |
| HGNC:6857 | MAP3K5 | isa |
| HGNC:29798 | MAP3K21 | isa |
| FPLX:TAOK | TAOK | isa |
| FPLX:RAF | RAF | isa |
| HGNC:6858 | MAP3K6 | isa |
| HGNC:6849 | MAP3K10 | isa |
| HGNC:17797 | MAP3K20 | isa |
| HGNC:6851 | MAP3K12 | isa |
| HGNC:31689 | MAP3K15 | isa |
| HGNC:6859 | MAP3K7 | isa |
| HGNC:6861 | MAP3K9 | isa |
| HGNC:6848 | MAP3K1 | isa |
| HGNC:6850 | MAP3K11 | isa |
| HGNC:6852 | MAP3K13 | isa |
| HGNC:6854 | MAP3K2 | isa |
| HGNC:6860 | MAP3K8 | isa |
| HGNC:6853 | MAP3K14 | isa |
| HGNC:26249 | MAP3K19 | isa |
| HGNC:6856 | MAP3K4 | isa |
| HGNC:6855 | MAP3K3 | isa |