MRN_complex

The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex binds avidly to double-strand breaks both in vitro and in vivo and may serve to tether broken ends prior to repair by non-homologous end joining or to initiate resection prior to repair by homologous recombination. The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage. Production of short single-strand oligonucleotides by Mre11 endonuclease activity has been implicated in ATM activation by the MRN complex. (hgnc.genefamily:1344)

Cross-references

• HGNC_GROUP:1344

Synonyms

Synonym	Reference	Specificity
Mre11/Rad50 (M/R) DNA-repair complex		Exact
MRN complex		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:7652	NBN	partof
HGNC:26157	WDCP	partof
HGNC:7230	MRE11	partof
HGNC:9816	RAD50	partof

Outgoing Relations

None available.